UCB aspires to be the patient-centric global biopharmaceutical leader transforming the lives of people living with severe diseases. We focus on central nervous system and immunology disorders. Our promise is to help tackle the serious unmet medical needs affecting patients around the globe. An important part of our philosophy is to take a holistic approach to patients, which aims to find solutions tailored to their circumstances. By taking into account patients’ individual characteristics and lifestyles, such as age, diet, family history and genetic profile, we are also coming closer to providing personalized therapies. We now have an exciting opportunity in the New Medicines department at our research site in Belgium, close to Brussels (Braine l’Alleud):
Non Clinical Drug Discovery Lead, Biomarkers Translational approach on safety assessment
- Provide scientific & technical leadership with in vitro toxicology, investigative and mechanistic toxicology and biomarkers expertise to support the entire molecule portfolio. Provide expertise on the molecular, cellular mechanisms of toxicity and translational biomarkers underlying the development of compound-related toxicities and/or diseases, through to post-approvals.
- Participate and drive the biomarker identification/validation efforts at the group level
- Develop, disseminate and implement a strategy for safety biomarkers, that includes in vivo and in vitro approaches and that has a translational perspective, to support mechanistic toxicology assessment
- Manage a biomarker laboratory (1 scientist, 1postdoc & 2 students)
- Develop and set up novel experimental models to support safety/mechanistic investigative molecular toxicology studies with the possibility of technical transference (= outsourcing) to CROs.
- Design, implement, interpret investigative and mechanistic molecular & biomarkers studies or participate as Principal Investigator with conventional and state of the art techniques.
- Attend scientific congresses and publish abstracts and/or papers in scientific journals
- Establish internal and external collaborations in the field of safety biomarkers and/or mechanistic toxicology
- Strong communication skills and the ability to work within cross-functional teamsDevelop appropriate collaboration with external partners, academic institutions, CROs and consultant toxicologists. Provide outstanding toxicology assessments of non-clinical safety studies and provide input in the biomarker identification / validation effort.
Provide significant contributions to project teams as an investigative safety specialist / representative to support the development of new innovative medicines.
- PhD or equivalent (MD, DVM, in biological sciences or related field)
- Min 10 years post-doc experience in in vitro toxicology, biomarkers and in cellular and molecular techniques
- Strong knowledge on the different types of biomarkers to select optimal approaches to be used in in vitro and in vivo experiments
- Hands on experience in various techniques including qualitative and quantitative biomarker analysis, immunoassays, flow cytometry, and immunocytochemistry.
- Prior experience in management (i.e. students, postdocs, laboratory support staff) would be desirable - Motivated scientist with good communication skills, able to work successfully in interdisciplinary teams - Excellent planning skills to successfully drive laboratory-based activities.
For further info please contact Jean-Pierre Valentin, +32494578307, Jean-Pierre.Valentin@ucb.com