Monitoring Microorganisms Metabolic Heterogeneity
ESPCI Paris is a major institution of higher education (a French "Grande École d’ingénieurs"), an internationally renowned research centre (6 Nobel Prizes), and a fertile ground of innovation for industry (3 start-ups created/year). ESPCI is a highly multidisciplinary environment with teaching and research in physics, chemistry and biology.
The institute for Chemistry Biology and Innovation (CBI) is a new laboratory gathering 5 teams having a common aim for scientific creation and technological innovation at the interface between chemistry and biology. The team “Colloïdes et Matériaux Divisés” (LCMD) have especially developed droplet-based microfluidic methods that enable massively parallel characterization of cells, for fundamental and applied research in microbiology, immunology and cancer diagnostics. The institute has a proven experience in successfully transferring their scientific results into successful start-ups: 10 start-ups, including Capsum, Kapsera and HiFiBiO Therapeutics.
Government policies recommend the development of sustainable microbial processes for the production of biobased compounds. Nevertheless, the use of complex mixtures of substrates issued from the deconstruction of biomass leads to delays that are detrimental to biotechnological processes. These delays include long transition periods when microorganisms switch between carbon sources. The partners of this project have recently discovered that these transition phases favor the emergence of metabolically different subpopulations in the same monoclonal population, thus contradicting the commonly accepted model of homogeneous adaptation of the population. Our ambition is therefore to understand the role and regulation of these subpopulations, and thus to use this metabolic heterogeneity as a lever for improving biotransformation processes.
This project involve two groups, located in the CBI laboratory and in the Toulouse Biotechnology Institute.
The role of the postdoc will be to use droplets microfluidics to monitor the emergence of metabolic heterogeneity at the single bacteria level.
We are seeking a highly motivated Postdoc, ideally with a strong experience in microfluidics. Image analysis skills will be valued. The candidate should be interested in learning microbiology basics. Flexibility, autonomy, the ability to work in a highly multidisciplinary team and good interpersonal skills are essential.
We offer an exciting and collaborative work environment at the forefront of biology, chemistry and physics research with top academic and industrial partners. We offer a competitive salary for an 18 months period.
Address your applications (CV + cover letter) to:
Jean BAUDRY (firstname.lastname@example.org)
ESPCI Paris – CBI Laboratory
10 Rue Vauquelin
75005 Paris - FranceMeer informatie
|Titel||Postdoctoral position in Microbiology and Microfluidics|
|Job location||10 Rue Vauquelin, 75005 Paris|
|Gepubliceerd||oktober 11, 2019|
|Vakgebieden||Biotechnologie,   Microbiologie,   Beeldverwerking,   Bacteriologie  |