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King Abdullah University of Science and Technology (KAUST)

Postdoc in Genome and Chromatin Organization

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The “Chromatin Biochemistry” laboratory of Prof. Wolfgang Fischle at KAUST invites applications for a Postdoc position in “Genome and Chromatin Organization”.

Our research team is aiming to understand the molecular principles of epigenetic regulation that are embedded in the organization of cellular chromatin. In the continuation of an ongoing research project, we want to investigate the molecular details of heterochromatin and so called ‘B’ compartments. A particular focus is on repressive histone modifications, their binding proteins and non-coding RNAs. We are using the model system C. elegans to address how heterochromatin compartments are established and maintained. The experimental approaches range from genetics and genomics to molecular cell biology and different high throughput mapping experiments (e.g. HiC, ChIP-seq, ATAC-seq, etc.) in ensemble and at single cell level.

The research team is very diverse in background and nationalities and provides a highly stimulating working environment. We now seek a dynamic new colleague who wants to drive a project at the forefront of genome and epigenetics research.

Major Responsibilities

The successful candidate is expected to develop several C. elegans lineages mutant for different heterochromatin factors and analyze their impact on 3D genome organization. Further, consequences of deficiencies in chromatin compartmentalization on a molecular (i.e. genome readout) and developmental (i.e. cell differentiation) level are to be investigated. To integrate the findings in a larger context, s/he will need to interface with other experimentalists in the research team as well as bioinformaticians to address a scientific question at the frontier of biological research.

Individuals must be able to work in a team and possess excellent communication skills. We expect high motivation, the ability to meet deadlines in a goal-oriented environment and the talent to organize personal and group work flows. Candidates must be accustomed to working under pressure and to contribute to scientific problem solving. High proficiency in English language is a must.

Applicants should hold a PhD in molecular biology or related disciplines. Experience with the model system C. elegans and/or systems biology workflows is a plus. We are seeking candidates who have a strong background in analyzing complex cellular regulatory systems paired with an interest in applying state of the art methodology and in solving cutting edge research problems. Scholars must have the skills to drive projects forward and to build fruitful interfaces with ongoing studies. Scientists with high motivation for basic research as well as the ability and desire to work in a multidisciplinary and international research environment are encouraged to apply.

Please provide a statement of research interest, CV and names and contact details of three referees.

The position is available immediately and until filled.

Informatie over de vacature

Functienaam
Postdoc in Genome and Chromatin Organization
Locatie
King Abdullah University of Science and Technology Thuwal, Saudi-Arabië
Gepubliceerd
2022-04-26
Uiterste sollicitatiedatum
Unspecified
Soort functie
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