The laboratory of professor Geert Carmeliet investigates the contribution of cell metabolism of different skeletal cell types to bone development, homeostasis, diseases and regeneration. The lab is looking for a dynamic, highly motivated postdoctoral researcher to join the team. Our recent work shows that metabolism of skeletal cells regulates bone development and is crucial in preventing osteoporosis and promoting bone regeneration (Stegen S., Cell Metab 2016; Stegen S., Nature 2019; van Gastel N., Nature 2020; Stegen S., Dev Cell 2020). Moreover, these studies reveal that targeting skeletal cell metabolism could be a possible therapeutic strategy to improve bone regeneration and to treat skeletal disorders such as osteoporosis and osteoarthritis. In addition, tumor cell metabolism seems to contribute to bone metastasis. The current aim of the lab is to characterize in-depth the metabolic regulation of different skeletal cell types. We combine advanced metabolic and transcriptomic analyses with state-of-the-art cell biological and molecular assays. The importance of the identified metabolic pathways will be validated by genetic and pharmacological approaches in cell cultures and in preclinical bone pathology models in mice.
You will work independently on your research project, but in close collaboration with other team members using in vitro approaches, in vivo mouse models and innovative and state-of-the-art technologies.
You will characterize the metabolic profile of certain skeletal cell types, investigate its importance for skeletal homeostasis and its contribution to disease states and initiate possible translation.
For more information, please contact prof. dr. Geert Carmeliet, tel.: +32 16 33 07 31, mail: email@example.com.
Your application file should contain a complete CV, motivation letter, list of publications, summary of past research and contact information or reference letter of 2 or 3 referees.
The KU Leuven is very international, close to Brussels, at the heart of Europe.
You can apply for this job no later than January 25, 2022 via the online application tool
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.
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