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Université catholique de Louvain

Postdoctoral Fellowship in Diabetes Research at UCLouvain, Brussels, Belgium

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Project: Direct and indirect mechanisms controlling glucagon and insulin secretion: therapeutic implications for diabetes

The endocrine pancreas plays a key role in glucose homeostasis. It is organized in islets mainly composed of beta, alpha- and delta-cells, secreting, respectively, insulin, glucagon and somatostatin. Insulin is the major hypoglycemic hormone whereas glucagon is hyperglycemic. Somatostatin potently inhibits the secretion of both insulin and glucagon. Diabetes is characterized by an impaired glucose homeostasis and results from a deficit in insulin which is absolute in type 1 diabetes (due to beta-cell destruction) or relative in type 2 diabetes (as a result of decreased beta-cell mass and insulin resistance). Diabetes is also characterized by a defective glucagon secretion (hypersecretion and altered response to hypoglycemia) of unknown origin. All the cell types of the islets influence each other, but the nature of these heterologous interactions is still poorly understood. The objectives of the project are to study the direct and indirect mechanisms controlling glucagon and insulin secretion, using various approaches, from the gene to the cell and to the whole organism in healthy states and in diabetes. One goal will be to identify new therapeutic targets to help to normalize glucose homeostasis in diabetes. Studies will be performed on both human and mouse tissue.

Fellowship: The postdoctoral position is open in December 2021 and will remain open until suitable candidates are found. Position is for two years, with a possibility of one-year extension. Fellowship starts from approximately 2550 €/month after tax

Profile: The applicant should have a PhD thesis in medical/biological sciences or equivalent that is not from our University. He/she should be in a position of international mobility, which requires that he/she should have spent at least one year outside Belgium during the 3 years preceding the beginning of the post-doc fellowship, and he/she cannot have defended his/her thesis more than 6 years before the start of the post-doc fellowship. The applicant should have a strong knowledge in biology and cellular physiology. A certificate of experimentation on laboratory animals is required. Experience in bioinformatics is a plus. The ability to write and speak in English is mandatory. Good communication skills and the ability to work both independently and as part of a team are required. The candidate should have demonstrable track record of research excellence.

Techniques used in the lab: Cell culture, Fluorescence-Activated Cell Sorting (FACS), gene expression analysis, secretion assays, live cell imaging, conventional and confocal fluorescence microscopy, patch-clamp, cloning and adenovirus construction, transgenic mouse models, ...

Environment: Our lab is composed of ~15 researchers including PhD students and post-docs from various nationalities. The lab is located in a pleasant area in Brussels.

Procedure: The applicant should send, in a single PDF file, to the email address below (i) a motivation letter, (ii) a detailed curriculum vitae mentioning the list of articles with the impact factor of the Journal, a phone number, an e.mail address, the birthdate, photo, copies of relevant university degrees  + certificate of experimentation on laboratory animals, and (iii) names, addresses, e.mail addresses and phone numbers of at least 2 (ideally 3) persons of reference.

To Dr. P. Gilon patrick.gilon@uclouvain.be

ADDITIONAL INFORMATION

Benefits

Fellowship: Starts from approximately 2550 €/month after tax

Eligibility criteria

The applicant should have a PhD thesis in medical/biological sciences or equivalent that is not from our University. He/she should be in a position of international mobility, which requires that he/she should have spent at least one year outside Belgium during the 3 years preceding the beginning of the post-doc fellowship, and he/she cannot have defended his/her thesis more than 6 years before the start of the post-doc fellowship. The applicant should have a strong knowledge in biology and cellular physiology. A certificate of experimentation on laboratory animals is required. Experience in bioinformatics is a plus. The ability to write and speak in English is mandatory. Good communication skills and the ability to work both independently and as part of a team are required. The candidate should have demonstrable track record of research excellence.

Selection process

Based on CV, motivation letter and letters from referees

Additional comments

Description of fellowship: Position is for two years, with a possibility of one-year extension. Fellowship starts from approximately 2550 €/month after tax.

The applicant should send, in a single PDF file, to the email address below (i) a motivation letter, (ii) a detailed curriculum vitae mentioning the list of articles with the impact factor of the Journal, a phone number, an e.mail address, the birthdate, copies of relevant university degrees + certificate of experimentation on laboratory animals, and (iii) names, addresses, e.mail addresses and phone numbers of at least 2 (ideally 3) persons of reference.

To Dr. P. Gilon patrick.gilon@uclouvain.be

REQUIREMENTS

Offer Requirements

REQUIRED EDUCATION LEVEL

Biological sciences: PhD or equivalent

Neurosciences: PhD or equivalent

Pharmacological sciences: PhD or equivalent

Medical sciences: PhD or equivalent

REQUIRED LANGUAGES

ENGLISH: Good

Skills/Qualifications

The applicant should have a PhD thesis in medical/biological sciences or equivalent that is not from our University. He/she should be in a position of international mobility, which requires that he/she should have spent at least one year outside Belgium during the 3 years preceding the beginning of the post-doc fellowship, and he/she cannot have defended his/her thesis more than 6 years before the start of the post-doc fellowship. The applicant should have a strong knowledge in biology and cellular physiology. A certificate of experimentation on laboratory animals is required. Experience in bioinformatics is a plus. The ability to write and speak in English is mandatory. Good communication skills and the ability to work both independently and as part of a team are required. The candidate should have demonstrable track record of research excellence.

Specific Requirements

The applicant should be in a position of international mobility, which requires that he/she should have spent at least one year outside Belgium during the 3 years preceding the beginning of the post-doc fellowship, and he/she cannot have defended his/her thesis more than 6 years before the start of the post-doc fellowship.

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Informatie over de vacature

Functienaam
Postdoctoral Fellowship in Diabetes Research at UCLouvain, Brussels, Belgium
Locatie
Place de l'Université 1 Louvain-la-Neuve, België
Gepubliceerd
2021-12-01
Uiterste sollicitatiedatum
2022-02-15
Soort functie
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The Université catholique de Louvain (UCLouvain) is internationally recognized for research and teaching quality in many different fields of expert...

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