Vagus nerve stimulation is an add on treatment for patients with refractory epilepsy. Despite its well-established use in clinical practice, mechanisms of action remain poorly understood and only one third of implanted patients respond to the treatment. This project aims to improve VNS therapy through the development of closed loop vagal nerve stimulation. Up till today, seizure detection is mainly based on scalp or intracranial EEG, nevertheless seizures also affect the autonomous system. For this reason, exploiting the vagal neural traffic with respect to seizures may offer an innovative way to detect seizures and allow the development of closed loop stimulation. We previously have described in our laboratory a reliable method to record vagus nerve electroneurogram (VENG) during acute induced seizures in anesthetized rats (Stumpp et al 2020, 2021). In a next step of this project, we plan to implant rats with a custom-made cuff electrode and determine whether spontaneous seizures can be detected through VENG recording. We also aim to study the natural variations of the VENG in function of circadian rhytm and bettre understand which physiological variatsion are linked to our VENg recordings
We are searching for a highly motivated student to start between 1/01/2022 and 1/02/2022 and. He/she will be based at UCL, located in Brussels (Belgium) and the project will be performed in close collaboration with all the partners. Your promotor will be Pr. Riëm El Tahry, neurologist at Cliniques Universitaires Saint Luc and PI at IONS, UCL, Pole NEUR. Your co-promoter will be Pr. Antoine Nonclercq, PI at BEAMS department, ULB. The PhD is financed for 3 years, extendable for 1 year if new fundings can be acquired.
Demanded profile: biology, biomedical or medical student with excellent degrees and specific interest for Neurosciences, showing knowledge, or the willingness to acquire it, in animal handling and surgery and willing to integrate in a multidisciplinary team consisting of neurologists, neurophysiologists and engineers. High interest in technological aspecst of the project is appreciated. Fluent English is required.
Application: Interested candidates are requested to send their application to Pr. Riëm El Tahry (firstname.lastname@example.org), with a copy to Pr. Antoine Nonclercq (email@example.com), and Pr. Jean Delbeke (firstname.lastname@example.org) , including a cover letter describing yourself and your interests, a resume, your ranking and at least 1 recommendation letter.
2 position(s) available at
Université catholique de Louvain
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|Titel||Vagus nerve stimulation for refractory epilepsy|
|Employer||Université catholique de Louvain|
|Job location||Place de l'Université 1, 1348 Louvain-La-Neuve|
|Gepubliceerd||september 14, 2021|
|Sluitingsdatum||december 1, 2021|
|Vakgebieden||Neurowetenschappen (Neurologie),   Biogeneeskunde,   Chirurgie  |