...

Collaborative research center (CRC) Chromatin Dynamics

Website bezoeken

Over de werkgever

The SFB 1064 collaborative research center (CRC) explores the nature of dynamic transitions of chromatin organisation. It aims to understand principles and mechanisms that endow chromatin organisation with diversity, flexibility and plasticity to respond to environmental, metabolic and developmental cues. CRC research strives for an integrated understanding of chromatin structure and function, involving identification and biochemical characterization of enzymes and metabolites, multi-omic analyses and imaging of cells in diverse physiological states and during ontogeny of model organisms.

Chromatin-based regulation relies on genome- and locus-specific chromatin organisation. We explore the chromatin landscape along the chromosomes defined by chromatin modification patterns, nucleosome remodelling, histone variants, associated proteome and polymer condensation of the chromatin fiber and how it changes during physiological and experimentally induced cell-fate transitions, nutrient availability and the DNA damage response. We observe how the three fundamental genome functions transcription, replication and maintenance of genome integrity and their unavoidable interference on the chromosome are accompanied by structural adaptation of chromatin.

In this third reporting period of this CRC (2021-2025), two transversal themes provide new viewpoints and opportunities for discovery:

  • Time lines in chromatin dynamics, where we consider mechanisms of reversible transitions (turnover), irreversible emergence of stable states (trajectory) and cyclical dynamics (cycle),
  • Intersections between local chromatin organisation and cell metabolism.

With 22 dedicated CRC projects, we look forward to four more productive and enlightening years of research in Chromatin Dynamics!

Locatie werkgever

Vergelijkbare werkgevers

...
KU Leuven Leuven, België 145 vacatures
...
University of Luxembourg Luxemburg 102 vacatures
...
Ghent University Gent, België 69 vacatures
Meer werkgevers

Dit vind je misschien ook interessant

...
5 Reasons to Pursue Your PhD at EMBL European Molecular Biology Laboratory (EMBL) Leestijd: 4 min
...
The genetic detectives discovering who we really are University of Turku Leestijd: 5 min
...
Deciphering the Gut’s Clues to Our Health University of Turku Leestijd: 5 min
...
Understanding Users to Optimise 3D Experiences Centrum Wiskunde & Informatica (CWI) Leestijd: 5 min
...
Harnessing the Rhizosphere to Protect Our Soil Free University of Bozen - Bolzano Leestijd: 5 min
Meer stories