PhD position in Molecular Modelling

We would like to announce a PhD position in molecular modeling of intrinsically disordered proteins constrained by EPR, cross-linking and NMR. Proteins in disperse and liquid-liquid phase separated state are going to be targeted. Addressing details of conformational distributions of intrinsically disordered proteins in dispersed and liquid-liquid phase separated state is a serious spectroscopic challenge. Here, we want to combine experimental data from several ongoing projects with coarse grained molecular modelling to unveil important details of such conformational distributions.

Project background

The primary objective for the candidate is to design, implement, and use a coarse-grained representation for intrinsically disordered proteins (IDPs). In particular, the resultant model will incorporate artificial and experimental EPR restraints and be used to run EPR-constrained molecular dynamics calculations to determine experimentally guided, conformational ensembles for IDPs of biological interest.

Job description

The four-year project is funded by ETH Zurich and will be supervised by Dr. Maxim Yulikov (ETH, Jeschke group) in cooperation with Dr. Andreas Vitalis (UZH, Caflisch group) and will benefit from the experimental input from several ongoing structural biology projects in the Jeschke group at ETH. It will be highly advantageous for candidates to have prior practical experience in setting up classical, molecular simulations and to possess excellent skills in physical chemistry and its mathematical foundations. Prior programming experience and good communication skills are a definite plus. To make the project successful, independent work will need to be efficiently combined with regular meetings and discussions, as well as practical cooperation with EPR, simulation, and molecular biology experts.

Profile

We expect from you:

Recently obtained master degree in physics, physical chemistry or in chemistry/biology with strong emphasis on physical chemistry and computational methods
Coding abilities in at least one language
Excellent proficiency in English as working language
Good soft skills for independent work and team-work
A keen interest in molecular modelling, in scientific methods and research in general
Knowledge and experience with setting up classical molecular simulations are a plus

We offer

Your career with impact: Become part of ETH Zurich, which not only supports your professional development, but also actively contributes to positive change in society.
We are actively committed to a sustainable and climate-neutral university.
You can expect numerous benefits, such as public transport season tickets and car sharing, a wide range of sports offered by the ASVZ, childcare and attractive pension benefits.

Working, teaching and research at ETH Zurich

We value diversity

In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish.

Curious? So are we.

We look forward to receiving your online application with the following documents:

CV
Cover letter

For any related questions, you can also come in person in the office HCI F231. In the evaluation process, two support letters from previous research project or university course supervisors will be requested. The starting date for this project cannot be later than 01.08.2025. We encourage interested candidates to apply as soon as possible: the position will be closed as soon as an appropriate candidate is found.

Questions regarding the position should be directed to Dr. Maxim Yulikov: [email protected].

About ETH Zürich

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.

Détails de l'offre

Titre

PhD position in Molecular Modelling

Employeur

ETH Zürich

Localisation

Rämistrasse 101 Zurich, Suisse

Publié

2025-04-23

Date limite d'inscription

Unspecified

Type de poste

PhD

Domaine

Biologie moléculaire, Génétique, Biochimie, Chimie moléculaire, Chimie physique et 2 supplémentaires

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