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Temporary Employment 1 Year with option of extension
Your Responsibilities
Conducting and writing a dissertation at the University of Graz under the supervision of Assoz. Prof. Dipl.-Biochem. Dr.rer.nat. Tobias Eisenberg
Conducting experiments and data analysis
Independent planning and evaluation of scientific experiments
Presenting and discussing data in regular internal and external meetings as well as at (inter)national conferences
Publishing in internationally renowned, peer-reviewed journals
Co-supervising students at the Bachelor's or Master's level
Opportunity to conduct part of the project in a host laboratory abroad
Your Profile
Completed diploma or master’s degree in the area of life sciences or natural sciences
Eligible as a graduate student at the University of Graz, Austria
Theoretical and practical knowledge in biochemistry, molecular and cell biology
Ideally, practical knowledge of working with Flow Cytometry
High level of commitment, personal initiative, and self-motivation for scientific work
Excellent knowledge of written and spoken English
High degree of personal responsibility and ability to cooperate
Excellent social skills and ability to work in a team..
The following documents are required for a complete application:
Motivation letter, including a ranking if multiple PhD projects are of interest
Academic CV including abstract of your Master Thesis
Proof of completion of the required degree as stated in the job posting
Two recommendation letters, which must be sent directly by the refeeres to [email protected] until the application deadline
Hearing 23. Juni 2025 in Graz
Autophagy in Chronic Inflammation during Aging- EISENBERG Tobias (MetAGE Key Researcher)
Background:
Aging is associated with chronic (sterile) inflammation and immunosenescence, processes that contribute significantly to age-related diseases. Autophagy, a cellular recycling pathway, plays a vital role in maintaining proteostasis and organelle homeostasis, ensuring proper immune cell function in older adults. Consequently, changes in autophagic activity are hypothesized to drive both immunosenescence and chronic inflammation. Irrespectively, the exact mechanisms by which aging and aging-associated conditions, including obesity, metabolic syndrome, and cardiometabolic dysfunction, influence autophagy in humans remain poorly understood. This gap in knowledge is partly due to past methodological limitations.
Hypothesis and Objectives:
We hypothesize that chronic inflammation derives from cell type-specific alterations in autophagy in an age-dependent manner, contributing to a vicious cycle between inflammation and autophagic dysfunction. By applying a novel method to assess autophagic flux, developed within the MetAGE framework, along with advanced single-cell technologies, this project aims to elucidate how autophagy is regulated in circulating immune cells in humans and animal models during aging and in response to geroprotective interventions. Additionally, we seek to understand how these autophagic changes are linked to chronic (sterile) inflammation.
Methodology:
As part of the MetAGE Cluster of Excellence, you will investigate the interplay between inflammation and autophagy using various assays, including autophagic flux measurements with flow cytometry. You will complement this with biochemical and omics analyses to explore inflammatory signaling pathways. Collaboration with the MetAGE consortium will provide access to both animal models and human samples from controlled trials and observational studies, enabling translation of preclinical findings into human aging research.
We offer an annual gross salary of € 52,007.20 for a fulltime position.
We Offer
Meaning: We offer meaningful work for the world of tomorrow.
Our internal continuing education program is as colorful as the university itself.
Collaboration: With us, you'll find interdisciplinary, cross-professional opportunities to work together.
Benefits: Of course, there are all the usual benefits, from A "access to healthcare services" to Z "Zero emission goal".
Diversity: Besides our various scientific fields and their related issues, we offer a working environment in which diversity is lived.
Flexibility: We demonstrate flexibility not only with the various working time models but also through the offers for the compatibility of family and career.
About us
At the University of Graz, 4700 employees work together on future questions and solutions for the world of tomorrow. Our students and researchers take on the major challenges of society and share their knowledge. We work for tomorrow. Be part of it!
The University of Graz strives to increase the proportion of women in particular in management and faculty positions and therefore encourages qualified women to apply. In the event of underrepresentation, women with equal qualifications are generally given priority for admission. We welcome applications from persons with disabilities who meet the requirements of the advertised position.
Please note that in order to comply with the applicable data protection regulations, we can only accept applications via our web-based applicant tool for this vacant position.
We work for tomorrow. Join us!
Job details
Title
MetAGE PhD Position: Autophagy in Chronic Inflammation during Aging (m/f/d)
Choosing the right university can be a challenging decision in a researcher's career. At the University of Graz, this choice is made easier by a unique combi...
